tetra-n-butyl ammonium hydroxide mediated one-pot synthesis of pyrano [2, 3-d] pyrimidinone derivatives

tetra-n-butyl ammonium hydroxide was used as a catalyst for one-pot, three component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric acid in ethanol:water solvent system at 60oc. current method has major advantages like mild reaction conditions with simple operation, high yields, by using a less toxic and lower costlier catalyst.in conclusion, we have explored nicely the synthetic utility of tbaoh as a commercially available, efficient, mild, straightforward, simple, environmentally and economically friendly organo-basic catalyst for the synthesis of diverse pyrano[2,3-d]pyrimidinone derivtives. thus we have developed a novel, simple and highly efficient one potmulticomponent reaction protocol for the synthesis of pyrano[2,3-d]pyrimidinone derivtives in ethanol:water solvent system.